Abstract: Objective： To detect the change of hypersensitive C-reactive protein (hs-CRP) and lipoprotein (a) (Lp (a)) between acute cerebral infarction patients and normal person. Also to study the different level of hs-CRP and Lp (a) according to different classification of acute cerebral infarction. Methods： The level of hs-CRP and Lp (a) among acute cerebral infarction patients and normal person were measured by using immunoturbidimetry. NIHSS score and OCSP and MRI to classify the clinical symptom of acute cerebral infarction patients were undergone. SPSS 13.0 was used to analysis all the data. Results： The level of hs-CRP (7.79±1.12 mg/L, n=200) and Lp (a) (265.32±19.86 mg/L, n=200) of acute cerebral infarction were higher than that of normal person, hs-CRP (0.59±1.12 mg/L, n=100) and Lp (a) (30.49±1.72 mg/L, n=100) respectively (P< 0.05). The level of hs-CRP (10.18±1.77 mg/L, n=114) and Lp (a)(319.40±31.40 mg/L, n=114) of anterior circulation infarction were higher than that of posterior circulation infarction, hs-CRP (4.62±1.01 mg/L, n=86)and Lp (a) (193.64±17.42 mg/L, n=86), respectively (P< 0.05). The level of hs-CRP(19.34±4.82 mg/L, n=25) from severe team (≥10) was higher than that of moderate team (5-9)(6.87±2.14 mg/L, n=32) and mild team (0～4)(6.00±1.16 mg/L, n=143) respectively, according to the score of NIHSS(P< 0.05). There were no statistic difference of Lp (a) among these three teams according to the score of NIHSS. According to the classification of OCSP, the level of hs-CRP of TACI (22.33±5.5 mg/L, n=21) was higher than that of PACI (9.32±2.76 mg/L, n=54), POCI(6.01±1.75 mg/L, n=40) and LACI(4.02±0.79 mg/L, n=85)，respectively (P< 0.05). There was no statistic difference of Lp (a) among different teams according to OCSP. Conclusions： hs-CRP and Lp (a) are independent risk factors of the acute cerebral infarction. The level of hs-CRP and Lp (a) of acute cerebral infarction patients are higher than that of normal person. The level of Lp (a) of anterior circulation infarction is higher than that of posterior circulation infarction. This result may indicate that Lp (a) may have the value to indicate the position of acute cerebral infarction. The level of hs-CRP may have a relationship with severity of acute cerebral infarction and also it may have the value to indicate the position of acute cerebral infarction.