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崔晓通, 王鹏, 金雪娟, 等. 中国不同射血分数亚型心力衰竭住院患者临床特征分析[J]. 中国临床医学, 2023, 30(5): 759-762. DOI: 10.12025/j.issn.1008-6358.2023.20231513
引用本文: 崔晓通, 王鹏, 金雪娟, 等. 中国不同射血分数亚型心力衰竭住院患者临床特征分析[J]. 中国临床医学, 2023, 30(5): 759-762. DOI: 10.12025/j.issn.1008-6358.2023.20231513
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CUI Xiao-tong, WANG Peng, JIN Xue-juan, et al. Clinical characteristics of hospitalized heart failure patients with different ejection fraction in China[J]. Chin J Clin Med, 2023, 30(5): 759-762. DOI: 10.12025/j.issn.1008-6358.2023.20231513
Citation: CUI Xiao-tong, WANG Peng, JIN Xue-juan, et al. Clinical characteristics of hospitalized heart failure patients with different ejection fraction in China[J]. Chin J Clin Med, 2023, 30(5): 759-762. DOI: 10.12025/j.issn.1008-6358.2023.20231513
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中国不同射血分数亚型心力衰竭住院患者临床特征分析

Clinical characteristics of hospitalized heart failure patients with different ejection fraction in China

    摘要
  • 摘要:
    目的 比较中国慢性心力衰竭（心衰，HF）患者3种不同左心室射血分数（LVEF）亚型的临床特征。
    方法 基于中国住院患者心力衰竭（CN-HF）注册研究（NCT02079428）入组患者数据，根据LVEF将患者分为3组：LVEF降低（≤40%）组（HFrEF组）、LVEF轻度降低（41%~49%）组（HFmrEF组），以及LVEF保留（≥50%）组（HFpEF组）。比较各组患者的临床特征。
    结果 共纳入5 605例住院心衰患者，男性占59.9%，平均年龄（69.5±13.5）岁。与HFrEF组（n=2 068）相比，HFpEF组（n=2 941）女性较多（48.5% vs 29.1%），且年龄(71.1±12.9)岁 vs (66.9±13.9)岁较大，纽约心脏病协会（NYHA）心功能分级Ⅲ~Ⅳ患者较少（43.3% vs 73.7%），高血压更常见(74.3% vs 64.3%)。3组间性别、年龄、心功能分级及高血压发生率差异均有统计学意义（P＜0.000 1)。所有患者3年全因死亡率为20.7%，HFrEF组、HFmrEF组和HFpEF组患者依次为26.4%、21.6和16.5%（Z=8.507 4；P＜0.001）。
    结论 与HFrEF患者相比，我国住院的HFpEF患者年龄大、女性多见、合并症发生率较高，但3年随访期间预后相对较好。

     

    Abstract:
    Objective To investigate the clinical characteristics among three different left ventricular ejection fraction (LVEF) subtypes of patients with chronic heart failure (HF) in China.
    Methods The data were from China National Heart Failure (CN-HF) registry (NCT02079428). Patients were categorized into three groups based on their LVEF: HF with reduced ejection fraction (≤40%) group (HFrEF group), HF with mildly reduced ejection fraction (41%-49%) group (HFmrEF group), and HF with preserved ejection fraction (≥50%) group (HFpEF group). Basic characteristics in each group were analyzed and compared.
    Results A total of 5 605 hospitalized patients with HF were enrolled in this real world registry study (mean age was 69.5±13.5 years old, 59.9% were male). Compared to HFrEF group (n=2 068), HFpEF group (n=2 941) had more females (48.5% vs 29.1%) and patients were older (71.1±12.9 years old vs 66.9±13.9 years old), with less New York Heart Assocation (NYHA) Ⅲ-Ⅳ ones (43.3% vs 73.7%), and more hypertension patients (74.3% vs 64.3%). There were significant difference among the three groups in gender, age, NYHA grade and hypertension rate (P < 0.000 1). The 3-year all-cause mortality rate was 20.7% in all patients, 26.4%, 21.6, and 16.5% in HFrEF, HFmrEF, and HFpEF patients, respectively (Z=8.507 4, P < 0.001).
    Conclusions Compared with HFrEF patients, HFpEF patients are older, more often women, and have a higher prevalence of comorbidities, and have a relatively favorable prognosis during 3 year follow-up.

     

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