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齐保振, 谢钟磊, 沈冬丽, 等. 钠离子通道1.8对急性心肌梗死后心房颤动发生的调控作用[J]. 中国临床医学, 2023, 30(2): 301-305. DOI: 10.12025/j.issn.1008-6358.2023.20221932
引用本文: 齐保振, 谢钟磊, 沈冬丽, 等. 钠离子通道1.8对急性心肌梗死后心房颤动发生的调控作用[J]. 中国临床医学, 2023, 30(2): 301-305. DOI: 10.12025/j.issn.1008-6358.2023.20221932
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QI Bao-zhen, XIE Zhong-lei, SHEN Dong-li, et al. The regulation effect of NaV1.8 channels on atrial fibrillation inducibility after acute myocardial infarction[J]. Chin J Clin Med, 2023, 30(2): 301-305. DOI: 10.12025/j.issn.1008-6358.2023.20221932
Citation: QI Bao-zhen, XIE Zhong-lei, SHEN Dong-li, et al. The regulation effect of NaV1.8 channels on atrial fibrillation inducibility after acute myocardial infarction[J]. Chin J Clin Med, 2023, 30(2): 301-305. DOI: 10.12025/j.issn.1008-6358.2023.20221932
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钠离子通道1.8对急性心肌梗死后心房颤动发生的调控作用

The regulation effect of NaV1.8 channels on atrial fibrillation inducibility after acute myocardial infarction

    摘要
  • 摘要:
    目的 探讨阻断心脏神经节丛（ganglionated plexi, GP）的电压门控钠离子通道1.8（NaV1.8）对急性心肌梗死后心房颤动发生的影响。
    方法 将12只雄性比格犬随机分为A-803467组（NaV1.8阻断剂, n＝6）及对照组（DMSO, n＝6）。构建急性心肌梗死模型后，A-803467组于4个主要GP表面多点注射A-803467（1 μmol/0.5 mL），对照组注射DMSO（1 μmol/0.5 mL）。记录用药前及用药后30 min、60 min及90 min，两组犬的窦性心率、心房有效不应期、心房易损窗口及心房颤动持续时长的变化情况；记录用药后10 min高频电刺激（20 Hz, 0.1 ms, 方波）右前GP引起的窦性心率变化情况。
    结果 与对照组相比，A-803467可提高窦性心率，显著缩短心房有效不应期，增宽心房易损窗口，延长心房颤动时长。此外，A-803467可抑制高频电刺激右前GP导致的窦性心率减慢。
    结论 阻断GP的NaV1.8可提高急性心肌梗死后心房颤动的诱发性。NaV1.8可调控急性心肌梗死后心房颤动的发生，其作用机制可能与调控心脏GP的功能有关。

     

    Abstract:
    Objective To explore the effects of blocking NaV1.8 channels in cardiac ganglionated plexi (GP) on atrial fibrillation after acute myocardial infarction.
    Methods A total of 12 male beagles were randomly enrolled. NaV1.8 channels blocker A-803467 (n＝6) or DMSO (n＝6, control) was injected. Sinus rate (SR), atrial effective refractory period (AERP), the atrial cumulative window of vulnerability and duration of atrial fibrillation were measured before and 30 min, 60 min, 90 min after A-803467 or DMSO injection. The SR changes induced by high-frequency electrical stimulation (20 Hz, 0.1 ms, square wave) in the right anterior GP were recorded 10 min after injection.
    Results Compared with the control group, A-803467 significantly increased SR, shortened the AERP, widened the atrial cumulative window of vulnerability and prolonged the duration of atrial fibrillation. In addition, A-803467 suppressed the SR slowness induced by high-frequency electrical stimulation of the right anterior GP.
    Conclusions Blocking NaV1.8 increases the atrial fibrillation inducibility after acute myocardial infarction, and the underlying mechanism may be related to the regulation of the neural activity of the cardiac GP.

     

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