叉头框蛋白O3介导Th1/Th17/Treg失衡在白塞综合征发病机制中的潜在作用

The potential role of forkhead box O3 mediated Th1/Th17/Treg imbalance in the pathogenesis of Behçet's syndrome

摘要: 白塞综合征（Behçet's syndrome, BS）是一种慢性复发性、可累及多种重要脏器的变异性血管炎。免疫紊乱是BS发生发展的基石，其中辅助性T细胞（T helper cell, Th）1/Th17/调节性T细胞（regulatory T cell, Treg）失衡起重要作用。叉头框蛋白O3（forkhead box O3, FOXO3）可调节T细胞活化、分化和T细胞功能。FOXO3表达改变与Th1/Th17/Treg失衡相关，使FOXO3成为免疫疾病治疗的潜在靶点。目前尚缺乏FOXO3与BS相关的研究，故本文对FOXO3作为BS潜在治疗靶点的机制进行总结与展望。

Abstract: Behçet's syndrome (BS) is a chronic recurrent variant vasculitis involving multiple important organs. The immune disorder is the basis of occurrence and development of BS, and the imbalance of T helper cell (Th) 1/Th17/regulatory T cell (Treg) plays an important role. Forkhead box O3 (FOXO3) can modulate the activation, differentiation, and function of T cells. The change of FOXO3 expression is related to the imbalance of Th1/Th17/Treg, which makes FOXO3 a potential target for the treatment of immune diseases. At present, there is few research on FOXO3 and BS, so this paper summarizes and looks forward to the mechanism of FOXO3 as a potential therapeutic target for BS.