Abstract: Long non-coding RNA (lncRNA) play important roles in cancer progression. Studies have shown that as a lncRNA, prostate cancer associated transcript-1 (PCAT-1) is aberrant overexpressed in varieties of cancers, which is closely correlated to the proliferation, apoptosis, invasion, metastasis of tumor cells and the prognosis of tumor patients, however, the mechanism is not well elucidated. In this review, PCAT-1 as a new molecular marker or potential target is described in terms of tumor diagnosis, treatment and prognosis.