Abstract: Objective：To evaluate the feasibility of intraoperative infusion of sodium, potassium, magnesium, calcium, and glucose in patients with type 2 diabetes mellitus (T2DM). Methods：Thirty-two T2DM patients received lower extremity surgery under spinal anesthesia (ASAⅠ-Ⅱ) were randomly divided into the control group and the trial group. Patients in the control group were given sodium lactate Ringer’s injection (500 mL), and patients in the trial group were given sodium, potassium, magnesium, calcium and glucose injection (500 mL). The infusion was maintained at a steady speed and completed in 1 hour (60±5 min) with control system in both groups. The levels of hemodynamics, blood electrolytes, blood glucose, blood ketone, and arterial blood gas were detected at the time points of the morning before operation (T0), immediately after the start of infusion (T1), 30 min after the start of infusion (T2), immediately after the infusion of crystal liquid (T3), 30 min after the infusion of crystal liquid (T4), and before leaving the operating room (T5). Results：Compared to the preoperative (T1) values, the levels of blood glucose (T2-T5) of the control group (n=16) and the trial group (n=16) were significantly higher, the differences were statistically significant (P<0.05). The levels of blood glucose (T2-T5) of the trial group were significantly increased compared to the control group (P<0.05). The levels of the blood ketone increased in the control group (T3, T5) and decreased in the trial group (T3, T5), and the differences were statistically significant (P<0.05). There was no significant difference between the control group and the trial group about the levels of blood lactate, BE, pH, blood electrolytes and the index of circulatory states (T1-T5). Conclusions：The stable infusion of a small dose (500 mL) of sodium, potassium, magnesium, calcium and glucose injection during operation can reduce the formation of ketone body, however, the increase of blood glucose is obvious and therefore it is not suitable for routine infusion.