Abstract: As the development of minimally invasive technique, the concept of natural orifice transluminal endoscopic surgery (NOTES) emerges and has promoted the development of surgery. But there are a lot of problems. In the past decade, the technique of endoscopic resection has made great progresses, which gives new evolution to the development of NOTES. We reviewed the development of traditional NOTES and made a prospect to the development of new NOTES in this article.