Abstract: The cerebrovascular diseases, such as intracranial aneurysms and cerebrovascular stenosis, have become a major threat to human health. Pathological studies of cerebrovascular diseases have identified that vascular atherosclerosis is the basis of a series of cerebrovascular diseases. Recently, more and more studies have confirmed that Wnt signaling pathway is widely involved in the pathogenesis of cerebrovascular atherosclerosis. This review summarizes the research of Wnt signaling pathway in the dysfunction of vascular endothelial cells, macrophages, and smooth muscle cells, and explore the role of Wnt signaling in cerebrovascular atherosclerosis, hoping to provide a new direction for the future research of cerebrovascular diseases.