慢性痛风石发生机制研究进展

基金项目: 四川省科技厅青年基金(2016JQ0053)，国家重点研发计划“精准医学研究专项”(2016YFC0903503)，中华医学会燎原计划项目（LYJH-284）

Research progress on pathogenesis of chronic gouty tophus

摘要: 痛风石可导致关节活动受限、关节畸形。尿酸盐溶解度、离子浓度、结缔组织中因子和蛋白、中性粒细胞胞外网状陷阱等因素与尿酸钠(MSU)结晶的形成、增大密切相关。其中，尿酸盐浓度升高是唯一确定的MSU结晶形成的关键因素。
- 痛风石 /
- 发生机制 /
- 中性粒细胞胞外网状陷阱
Abstract: Gouty tophus contributed to joint activity limitation and deformation in patients. The urate solubility, concentration of ions, connective tissue proteins, and neutrophil extracellular traps factors all have relationship with the nucleation and growth of monosodium urate(MSU) crystal, among which, the increase of urate concentration is the only identified factor for the MSU crystallization.
- gouty tophus /
- pathogenesis /
- neutrophil extracellular traps