Abstract: Objective：To observe the influence of strengthen training of upper-limb on the rehabilitation of upper-limb and fingers function in stroke patients and evaluate the effect of this training on post stroke depression. Methods：One hundred patients at the first onset of stoke and hemiplegia in our hospital from January 2017 to May 2017 were recruited. They were randomly divided into the train group (n=50) and control group (n=50). The control group were treated with conventional rehabilitation therapy only. The train group were treated with conventional therapy and strengthen training. They were assessed with Fugl-Meyer Assessment (FMA), Barthel Index (BI), and NIHSS before and after treatment. Patients with post stroke depression in both groups received paroxetine hydrochloride treatment. In addition, the train group received strengthen training. They were evaluated with HAMD before and after treatment. Results：Six months after the treatment, the scores of FMA, FMA of upper-limb, FMA of fingers, and NIHSS were higher in the train group than those in the control group, and the differences were statistically significant (P<0.05).There was no significant difference in the scores of BI between the two groups. Six months after the treatment, the HAMD scores of both groups decreased significantly, and the train group scored better than the control group with significant difference (P<0.05). Conclusions：For patients with stoke and hemiplegia, strengthen training of upper-limb can improve the function of the upper-limb and the fingers, which is important to improve patients’ quality of life. It can also relieve patients’ degree of depression.