基于血管平滑肌视角的牵张应力对血管重构影响的研究进展

Effect of stretch stress on vascular remodeling--from perspective of vascular smooth muscle: recent progress

摘要: 血管重构（vascular remodeling）是众多心血管疾病发生发展的始动因素和最终归宿。动脉粥样硬化、高血压、肺动脉高压及冠状动脉支架植入均可引起不同程度的血管重构。牵张应力（stretch stress）是由搏动血流产生的作用于血管壁的一种生物机械力，异常的牵张应力作用于血管平滑肌细胞（vascular smooth muscle cells, VSMCs）可引起动脉硬化、冠脉支架内再狭窄等一系列事件。因此，本文旨在从血管平滑肌细胞的角度就牵张应力对血管重构的影响作一综述。

Abstract: Vascular remodeling is both the initiating factor and final destination in various cardiovascular diseases.Different extents of vascular remodeling participate in the pathophysiology progress of atherosclerosis, hypertension and coronary artery stenting. Stretch stress is a biomechanical force generated by pulsatile blood flow. Abnormal stretch stress acts on smooth muscle cell can result in events such as atherosclerosis and in-stent restenosis, etc.The purpose of this review is to summarize the effects of stretch stress on vascular remodeling from the perspective of vascular smooth muscle cells, in order to provide insights into the research of atherosclerosis and hypertension as well as the development of next generation of bioresorbable vascular scaffold.