Abstract: Objective：To compare the diagnostic efficacy of virtual touch tissues quantification (VTQ) and gray-scale ultrasound in liver cirrhosis. Methods：Gray-scale ultrasound was performed in 102 patients who underwent liver biopsy or liver operation. And the Glisson capsule, echo of hepatic parenchyma and spleen size were scored. The liver stiffness measurements were also performed by ACUSON S2000. The receiver operating characteristic curve (ROC) was constructed respectively to compare the diagnostic efficacy of the two methods for liver cirrhosis taking pathological findings as gold standard. Results：Pathological findings showed that there were 7 cases of stage S0, 9 cases of stage S1, 13 cases of stage S2, 21 cases of stage S3 and 52 cases of stage S4. The area under ROC of VTQ and gray-scale ultrasound in diagnosing liver cirrhosis was respectively 0.876 and 0.830, with significant difference (P=0.000). Conclusions：VTQ is superior to gray-scale ultrasound in diagnosing liver cirrhosis and can offer valuable information for clinical treatment.