Abstract: Liver ischemia-reperfusion injury is the leading cause of delayed recovery of liver function and dysfunction after operation. Some studies have shown that PI3K/Akt signaling pathway is activated during ischemia and reperfusion, which plays a protective role on the liver by inhibiting or enhancing the expressions of downstream target proteins. Therefore, PI3K/Akt signaling has become an important target pathway for preventing and improving hepatic ischemia-reperfusion injury. This review summarized the research progresses of PI3K/Akt signaling pathway in hepatic ischemia-reperfusion injury.