Abstract: Objective：To evaluate the value of intravenous iron combined with erythropoietin during perioperative period of cardiac surgery. Methods：Eighty patients undergoing cardiac surgery who were given intravenous iron combined with erythropoietin from January 2016 to July 2017 were retrospectively analyzed.The intravenous iron combined with erythropoietin was given on the operative day for those with Hb＞90 g/L, and was given 3-4 days before operation for those with Hb of 70-90 g/L, both lasting for 3-4 days. Control group was set without administration of intravenous iron and erythropoietin. The ascending range of Hb,rate of transfusion,volume of transfusion, incidence of infection and postoperative hospitalization were compared between groups. Results：In intravenous iron＋erythropoietin group, the level of Hb increased from (96±5) g/L to (123±9) g/L (2 weeks after operation), the rate of transfusion was 22.5% (18/80), the volume of transfusion was (430.7±41.5) mL, the incidence of infection was 5% (4/80) and the postoperative hospitalization stay was (6.2±1.7) days. In control group, the level of Hb increased from (98±6) g/L to (101±6) g/L (2 weeks after operation), the rate of transfusion was 37.5% (30/80), the volume of transfusion was (705.8±63.8) mL, the incidence of infection was 12.5% (10/80), and the postoperative hospitalization stay was (9.5±2.2) days. Above indexes in intravenous iron＋erythropoietin group were all better than those in control group (P<0.05). Conclusions：Administration of intravenous iron combined with erythropoietin during perioperative period of cardiac surgery can increase the Hb level and decrease the rate of transfusion, volume of transfusion, and incidence of infection, which is useful for recovery and less complications.