Abstract: Objective：To explore the effects of skeletal-related events (SREs) on survival in breast cancer patients with bone metastases. Methods：The breast cancer patients with bone metastases in Zhongshan Hospital affiliated to Fudan University and Huangpu District Central Hospital in Shanghai were collected, and divided into SREs group and non-SREs group. The basic clinical characteristics and bone metastases characteristics were compared between two groups. The characteristics of SREs were observed and the effects of SREs on bone survivals (BS) and overall survivals (OS) were analyzed. Results：Totally, 104 cases of breast cancer with bone metastases including 46 cases without SREs (non-SREs group) and 58 cases with SREs (SREs group) were enrolled. The age, type of surgery, histological type, stage of American Joint Committee on Cancer (AJCC), bone metastasis-free interval (BMFI), bone metastases sites were not significantly different between the two groups, while the number of bone metastases was significantly different (P=0.006). The time of skeletal-related events-free interval (SREFI) was from 0 to 48 months, with median time of 5.5(1.0，20.5) months. The most common SREs was bone pain (70.6%). No significant differences in BS （HR=1.043, 95%CI 0.608-1.790, P=0.878） and OS （HR=0.927, 95%CI 0.543-1.581, P=0.781） were noted between two groups. Conclusions：SREs do not increase the risk of death in breast cancer patients with bone metastases.