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胎儿期动脉导管血流异常对先天性右心系统畸形患儿预后的评估价值

Value of abnormal blood flow in fetal ductus arteriosus for prognostic evaluation of congenital right heart malformations

  • 摘要: 目的:探讨胎儿期动脉导管内血流变化对先天性右心系统畸形患儿出生后预后的预测和评价作用。方法:2015年2月至2017年2月产前诊断为先天性右心系统畸形的胎儿68例,依据胎儿期动脉导管血流变化,将其分为3组:A组(动脉导管内正向血流)、B组(动脉导管内双向血流)和C组(动脉导管内逆向血流)。随访至出生后6个月,分析各组患儿预后与其胎儿期动脉导管内血流方向变化的关系。结果:68例右心系统畸形胎儿中,A组31例(45.6%),B组25例(36.8%),C组12例(17.6%)。随着动脉导管内逆向血流的增多,肺动脉狭窄和肺动脉闭锁所占比例逐渐增高,且伴发右心室发育不良。39例随访至出生后6个月,A组和B组胎儿出生后一般情况尚可,且都能得到较好的双心室纠治;C组出生后预后相对较差,需要早期手术,且以单心室姑息手术为主。结论:动脉导管血流逆向胎儿多合并复杂右心畸形,评估胎儿期动脉导管内血流可间接反映胎儿肺动脉及右心室发育程度,对右心系统畸形胎儿预后有较好的预测及治疗指导作用。

     

    Abstract: Objective:To investigate the value of blood flow in fetal ductus arteriosus for predicting and evaluating prognosis of congenital right heart malformations after birth. Methods:Totally 68 fetuses prenatally diagnosed as congenital right heart malformations from February 2015 to February 2017 were divided into 3 groups based on the blood flow in fetal ductus arteriosus: group A with forward blood flow, group B with bidirectional blood flow, and group C with reverse blood flow. The cases were followed up to 6 months after birth and the relationship of prognosis and blood flow change in fetal ductus arteriosus was analyzed. Results:There were 31 in group A (45.6%), 25 in group B (36.8%), and 12 in group C (17.6%). It was found that the proportion of pulmonary stenosis and pulmonary atresia combined right ventricular dysplasia heightened with the increase of reverse blood flow in ductus arteriosus. Totally 39 cases were eventually followed up to 6 months after birth. In group A and B, the general situation was well after birth and preferable biventricular correction could be taken. While in group C, the prognosis was relatively poor after birth and early operation was needed, in addition, single ventricle palliative surgery was the major approach. Conclusions:Reverse blood flow in fetal ductus arteriosus is more common in fetuses with complex right heart malformations. Assessment of blood flow in fetal ductus arteriosus has great value in predicting prognosis of fetal right heart malformations.

     

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