Abstract: Objective：To evaluate the safety and efficacy of transcatheter aortic valve replacement (TAVR) in 40 patients with aortic valve stenosis in our center. Methods：Totally 40 consecutive patients who underwent TAVR in our center were enrolled. The endpoints included success rate of operation, complications, follow-up results 30 days after operation, etc. Results：There were 27 males and 13 females with mean age of (78.3±5.0) years old. The success rate of operation was 100%. After operation, the mean aortic valve pressure gradient decreased significantly (［10.77±3.90］ mmHg vs ［61.80±18.62］ mmHg, P<0.001), while the mean flap area increased significantly (［1.80 ± 0.24］ cm2 vs ［0.65 ± 0.17］ cm2, P<0.001). The NYHA class was significantly improved (1.80±0.62 vs 2.95±0.75, P<0.001) after TAVR. One day after operation, there were 13 with paravalvular regurgitation (12 of mild cases and 1 of moderate case), 1 with acute occlusion of right coronary artery, 1 with valve dislodgement then ischemic stroke, and 1 with intractable pericardial effusion and pericardial tamponade. In the 30-day follow-up, the mortality rate was 2.5% (1 patient) and the incidence of permanent cardiac pacemaker for abnormal cardiac conduction was 10% (4 patients). Conclusions：TAVR is safe and effective for aortic stenosis patients with high-risk or surgical contradication in our country.