Abstract: Objective：To observe the effect of somatostatin combined with erythromycin on stress inflammatory factors after surgery for abdominal injury. Methods：Ninety patients undergoing surgery for abdominal injury at the Department of General Surgery, the First Affiliated Hospital of Hebei North University were selected and divided into the control group (30 cases), the single drug group (30 cases), and the combination group (30 cases) according to the treatment methods. The patients in the control group were treated routinely with oxygen inhalation, gastrointestinal decompression, nutrition support, and water electrolyte balance correction; the patients in the single drug group were treated with erythromycin on the basis of the control group; and the patients in the combination group were treated with somatostatin combined with erythromycin on the basis of the control group. The recovery time of bowel sounds, the first-exhaust time, the first-defecation time, and the average time of hospital stay were recorded. The serum cortisol (Cor), C-reactive protein (CRP), interleukin (IL)-6, and IL-10 levels before surgery and first, third, and fifth day after surgery were detected. Results：The recovery time of bowel sounds, the first-exhaust time, the first-defecation time, the average time of hospital stay in the combination group were significantly earlier than those in the control group and the single drug group, and the above parameters in the single drug group were significantly earlier than those in the control group (P<0.05). There was no difference among the three groups in serum Cor, CRP, IL-6, and IL-10 levels before the surgery. The above parameters gradually increased and then gradually decreased after the surgery. The Cor, CRP, and IL-6 levels on the first, third, fifth day after the surgery showed a trend that is: combination group ＜ single drug group ＜ control group (P<0.05), whereas an opposite trend was found for the IL-10 level; for the combination group, the serum levels of Cor and IL-6 on the fifth day after the surgery were close to those before the surgery (P<0.05), but for the single drug group and the control group, they were still higher than those before the surgery (P<0.05). Conclusions：Somatostatin combined with erythromycin has better effects on the serum levels of Cor, CRP, IL-6, and IL-10, which is beneficial to the quick recovery after the surgery.