Abstract: Objective：To observe the clinical effect of full thickness skin grafting of plastic surgery in the treatment of lower extremity venous extensive ulcer of simple varicosity of great saphenous vein. Methods：A total of 23 patients from January 2011 to December 2016 with lower extremity venous extensive ulcer of simple varicosity of great saphenous vein，who underwent great saphenous vein high ligation，stripping，varicose vein branch ablation and subfascial perforating vein surgery combined with full thickness skin grafting of plastic surgery. Results：The ulcers in 23 cases were all healed. There was no recurrence in six months to two years follow-up. Conclusions：For lower extremity venous extensive ulcer of simple varicosity of great saphenous vein，on the basis of the traditional operation，full thickness skin grafting of plastic surgery can improve the cure rate and decrease the recurrence rate.