Abstract: Objective：To investigate the prevalence and related risk factors of diabetic retinopathy (DR) among registered residents of type 2 diabetes mellitus in Jiading Industrial Zone Community Health Service Center, Shanghai. Methods：In this cross-sectional study, diabetic retinopathy was screened among registered residents with type 2 diabetes in Jiading Industrial Zone Community Health Service Center, Shanghai. The prevalence and risk factors of DR were evaluated by combining questionnaire and clinical examination. Results： Among 776 subjects who were chosen, 695 people completed the study, and the overall response rate was 89.56%. 26 cases were excluded because the refractive medium was opaque and the retina could not be seen clearly. DR was detected in 91 patients (13.60%). The mean duration of diabetes in patients with DR and without DR was (9.63±6.44) years and (7.02±5.32) years (OR=1.073, 95% CI 1.036-1.111, P<0.001), the fasting blood glucose was (8.66±2.66) mmol/L and (7.52±2.15) mmol/L (OR=1.219, 95% CI 1.119-1.328, P<0.001), glycated hemoglobin was (7.68±1.55)% and (6.99±1.21)% (OR=1.495, 95% CI 1.275-1.754, P<0.001), and the differences were all statistically significant. There was also statistically significant difference in the use of insulin between DR patients and non-DR patients (OR=4.202, 95% CI 2.504-7.051, P<0.001). Conclusions： The prevalence of DR among type 2 diabetes patients is 13.6% in Jiading Industrial Zone, Shanghai. The longer the duration of diabetes is, the higher the fasting blood glucose is, the higher the glycosylated hemoglobin is, the greater the risk of DR will be.