Abstract: Objective：To study the correlation between the coronary slow flow phenomenon (CSFP) and blood uric acid (UA), homocysteine (Hcy), hematocrit (Hct) and red blood cell distribution width (RDW). Methods：The data of coronary angiography (CAG) patients with chest distress and chest pain were retrospectively analyzed. 121 patients with no obvious epicardial coronary artery stenosis but with coronary slow flow phenomenon were selected as the CSFP group (group SCF). 606 patients with completely normal epicardial coronary artery and normal blood flow were set as the normal blood flow group (group NCF). The differences of UA, Hcy, Hct and RDW between the two groups were compared, and the correlation between CSFP and the above indexes, UA and other biochemical indexes was analyzed.Results：The levels of UA, Hcy and Hct in group SCF were higher than those in group NCF (P< 0.001), but there was no significant difference in the level of RDW between the two groups. Conditional Logistic regression analysis showed that UA, Hcy and Hct were all risk factors of CSFP. Spearman correlation and partial correlation analysis showed that UA was positively correlated with Hcy. Conclusions：UA, Hcy and Hct are the risk factors for CSFP, and UA and Hcy may together promote the occurrence and development of CSFP.