Abstract: Objective：To evaluate the safety and effectiveness of one-stop hybrid therapy for triple-vessel coronary disease. Methods：Totally 34 patients with triple vessel coronary disease were treated by off-pump coronary artery bypass graft (OPCAB) combined with percutaneous coronary intervention (PCI) from Jan. 2011 to Jun. 2014. All 34 patients received PCI firstly, 46 stents implanted in coronary arteries, and then OPCAB were performed, 41 distal anastomosis were completed. Results：The one-stop hybrid procedure was successful in all patients. Selective coronary angiography immediately after one-stop hybrid procedure showed that grafts and stents were unobstructed．There was no death during the operation and perioperative period, no episodes of angina attack, no cardio-cerebrovascular events, no bleeding postoperatively and second exploratory thoracotomy. All patients remained free from angina，cardiac function improved significantly and no patient need medical intervention during the (36±8) months follow-up period. Conclusions：One-stop hybrid cardiac surgery provides a reasonable, feasible, and safe alternative for treating patients with coronary artery triple-vessel lesions, and it has good prognosis.