Abstract:
Objective:To investigate the clinicalpathological characteristics of ovarian immature teratoma and the effects of different surgery methods (cystectomy, salpingooophorectomy and hysterectomy+ bilateral salpingooophorectomy) on the prognosis of the patients and to analyze the role of cystectomy for apparent earlystage ovarian immature teratoma. Methods:Clinical data of 50 patients who were pathologically diagnosed with immature teratoma between Jul. 1997 and Aug. 2015 at the Obstetrics and Gynecology Hospital of Fudan University were analyzed retrospectively. According to the surgery methods, these patients were divided into three groups. The clinicalpathological characteristics and the prognosis of disease were compared. Results:All 50 cases were participated in the study. The followup time was 3207 months. FIGO stage as follows:ⅠA (34 patients), ⅠC1(10 patients), ⅠC2 (3 patients) and ⅡB, ⅢB and ⅢC (1 patient). Patients were divided into cystectomy group, salpingooophorectomy group and hysterectomy and bilateral salpingooophorectomy group. The five year diseasefree survival (DFS) was 100%,86.8%,100%, respectively. There were 45 patients underwent fertilitysparing surgery, 42 patients were the apparently early stage. No patient died among 50 cases, the total five year DFS rate was 91.0%.Among 50 cases, 4 cases were relapsed, and 3 cases had supplement surgery, 1 case was received assisted treatment, the postoperative pathology indicated that the recurrence was mature teratoma. Among 45 cases, 44 cases had normal period, only 1 case has shorten the period time. There were 13 patients with fertility requirements after surgery, including 11 cases of successful pregnant,and delivered 11 healthy infants, 2 cases were infertility (1 case due to tubal factor, 1 case of unexplained). Conclusions:Majority of patients are diagnosed with ovarian immature teratoma at an early stage. The data suggested that cystectomy could be considered for apparent earlystage patients affected by pure immature teratoma without adverse impact upon survival. Chemotherapy regimen is determined by pathological grade.