Abstract: Objective: To summarize early diagnosis and treatment experience of urosepsis so as to guide clinical work further. Methods: The clinical data of 15 patients with urosepsis treated in EICU of Xinhua Hospital, Shanghai Jiao Tong University School of Medicine were analyzed retrospectively. Results: Among 15 patients with urosepsis,there were 11 cases aged over 60 (73.33%), 14 female cases(93.33%),and diversified initial symptoms.The results of mid-stream urine bacterial culture were positive in 13 cases, of which 10 cases were E.coli(76.92%), 1 case was Enterobacter cloacae(7.69%), 2 cases were Enterococcus(15.39%). Acute physiology and chronic health evaluation Ⅱ score was positively correlated with procalcitonin level(r=0.728,P＜0.01),and negatively correlated with platelet level(r=－0.717,P＜0.01).Platelet level in the surgical intervention group was significantly lower than that in drug treatment group,and the difference was statistically significant(P＜0.05). Conclusions: Elderly women are at high risk of urosepsis. And the initial symptom is diversified, while Gram-negative bacilli are the main pathogens.The condition of patients with urosepsis can be effectively assessed by procalcitonin and platelet levels.