Abstract: Objective: To compare blood perfusion visibility of contrast-enhanced ultrasound (CEUS) in colorectal carcinoma (CRC) liver metastasis with contrast-enhanced computed tomography (CECT). Methods: Sixty cases of CRC liver metastasis in Zhongshan Hospital, Fudan University were enrolled in this study and were analyzed with both CEUS and CECT. Results: At arterial phase, 53.3%(32/60) lesions showed rim-like enhancement and 46.7% (28/60) lesions showed total enhancement on CEUS,while on CECT, rim-like enhancement, total enhancement and no enhancement were detected in 78.3% (47/60) lesions, 16.7% (10/60) lesions and 5% (3/60) lesions lesions, respectively (P＜0.01). At peak enhancement, 93.3% (56/60) lesions showed higher enhancement and 6.7% (4/60) lesions showed lower enhancement on CEUS,which were detected in 91.2%(52/57) lesions and 8.8%(5/57) lesions at arterial phase of CECT, respectively (P＞0.05). At portal venous phase, all lesions showed lower enhancement on both CEUS and CECT (P＞0.05). Conclusions: The blood perfusion appearance of CRC liver metastasis with CEUS is not identical as that of CECT. Among some cases, CEUS is superior to CECT on arterial perfusion visualization of liver metastasis.