Abstract: Objective: To explore the feasibility as well as mid-term and long-term clinical efficacy of self-locking and zero-profile cage for the treatment of multi-segmental cervical spondylosis. Methods: A total of 34 patients with cervical spondylosis, who received anterior cervical discectomy and fusion(ACDF) with new fusion cage for at least three segments during Oct. 2010 and Apr. 2013, were enrolled.The neural and cervical function was evaluated with Japanese Orthopedic Association(JOA) scores and neck disability index(NDI) before surgery, 3 months after surgery, 12 months after surgery and at the last follow-up.Meanwhile,the cervical curvature and intervertebral height were evaluated by X-ray at each time point and then compared with that before surgery.And the condition of cervical fusion was assessed by three-dimensional computed tomography scan. Furthermore, dom evaluation system was used to evaluate patients′ satisfaction after operation. Results: The follow-up averaged 24.3 months (range 18-30 months).There were significant differences between the JOA and NDI scores at the 3rd,12th month after operation and the last follow-up and that at preoperative point(P＜0.05).The angles of cervical curvature and intervertebral height were improved postoperatively (P＜0.05) and maintained throughout the follow-up.CT scan demonstrated that the precise fusion rate and the total fusion rate were 62.4% and 85.1% respectively at the 6th month after operation. And the precise fusion rate, the total fusion rate, the excellent and good rate were 93.1%, 100%, and 88.2%(30/34), respectively, at the 12th month after operation. Conclusions: The self-locking and zero-profile cervical cage could be applied in multi-segmental ACDF. It could maintain the cervical curvature as well as the intervertebral height after wide rage decompression, and assure the success of fusion as well as the satisfactory outcome.