Abstract: Objective: To explore the influence of different transport modes on the efficacy of direct percutaneous coronary intervention (PCI) in patients with acute ST-elevation myocardial infarction (STEMI). Methods: A total of 268 STEMI patients undergoing emergency PCI during Jan 2013 and Dec 2014 were selected. Among them, there were 139 patients whose single-time 12-lead ECG results were scanned and sent to specified cardiologists’ cellphones by ambulances or community doctors via wechat app (chest pain center mode exploration group) and 129 patients who went to hospital by themselves(common treatment group). The door to balloon dilatation time (D-to-B), the probability of D-to-B shorter than 90 minutes(target rate), the mortality during hospitalization, the incidence of heart failure, the average hospitalization days and hospitalization cost were compared between the two groups. Results: The results of comparison between the chest pain center mode exploration group and the common treatment group were shown as below:the D-to-B time (86.4±4.5 min vs. 97.4±10.3min, P<0.01),hospital during mortality (2.9％vs9.3%, P<0.05), the incidence of heart failure(4.3% vs. 11.6％,P<0.05), the average hospitalization days(8.7±3.2 d vs. 10.9±4.5 d, P<0.05 and hospitalization costs(50 347±19 310 yuan vs. 58 102±41 178 yuan,P<0.05). And all the differences were statistically significant. Conclusions: Regional chest pain center mode can shorten the reperfusion time and reduce the short-term mortality for STEMI patients.