Objective  To explore the correlation between the triglyceride glucose-waist-to-height ratio (TyG-WHtR) and heart failure (HF) after acute myocardial infarction (AMI),(AMI-HF).

Methods Clinical data of AMI patients admitted to Department of Cardiology, Wuhan No.1 Hospital, from January 2020 to January 2024 were retrospectively collected. Triglycerides, fasting glucose, waist circumference, and height data were collected to calculate TyG-WHtR. The correlation between TyG-WHtR and AMI-HF was analyzed by logistic regression analysis. The receiver operating characteristic (ROC) curve was used to analyze the ability of TyG-WHtR in predicting AMI-HF.

Results A total of 572 AMI patients were included in the study, of whom 102 (17.8%) AMI patients developed HF within one year after surgery. The TyG-WHtR index in the HF group was significantly elevated compared to the group without HF (5.5±0.4 vs 4.7±0.3, P＜0.001). Multivariate logistic regression analysis showed that TyG-WHtR was an independent risk factor for AMI-HF. The area under curve (AUC) of 0.78 for TyG-WHtR in predicting AMI-HF (P＜0.001); the AUC of the combination of TyG-WHtR and PCI time in predicting AMI-HF was 0.81 (P＜0.001).

Conclusions The TyG-WHtR index is an independent risk factor for AMI-HF and can be an effective indicator for predicting the risk of postoperative HF in AMI patients.