邮件订阅 RSS 中文 | English
高级检索

基于CT的3D定量形状特征对原发性胃肠道间质瘤术后无病生存期的预测价值

Predictive value of 3D quantitative shape features based on CT for disease-free survival of primary gastrointestinal stromal tumors

    摘要
  • 摘要:
    目的  探讨基于术前增强CT的3D定量形状特征对原发性胃肠道间质瘤（gastrointestinal stromal tumors, GIST）患者行完全切除术后无病生存期（disease-free survival, DFS）的预测价值。
    方法  回顾性选择2010年1月至2016年12月在复旦大学附属中山医院接受肿瘤完全切除术并经病理诊断为原发性胃部GIST的154例患者。评估腹盆腔CT传统影像学特征和肿瘤3D定量形状特征，采用单因素及多因素Cox回归分析DFS的影响因素。提取截断值并采用Kaplan-Meier曲线进行生存分析。
    结果  最大三维直径（HR＝1.829, 95%CI 1.389～2.408, P＜0.001）和球面歧化（HR＝2.153, 95%CI 1.474～3.146, P＜0.001）是原发性胃部GIST术后DFS的独立风险因素。Kaplan-Meier曲线显示，最大三维直径＞90.5 mm或球面歧化＞1.5的原发性胃部GIST患者接受完全切除术后的DFS更短（P＜0.001）。
    结论  基于术前增强CT的3D定量形状特征参数（最大三维直径和球面歧化）对原发性胃部GIST患者术后DFS具有临床辅助诊断价值。

     

    Abstract:
    Objective To explore the predictive value of 3D quantitative shape features based on enhanced CT for disease-free survival (DFS) of primary gastric gastrointestinal stromal tumors (GIST) patients receiving curative resection.
    Methods From January 2010 to December 2016, a total of 154 patients with primary gastric GIST who received curative resection in Zhongshan Hospital, Fudan University were retrospectively collected. The conventional CT imaging features and 3D quantitative shape features of tumors were evaluated, and the influencing factors of DFS were analyzed by univariate and multivariate Cox regression. Cut-off values were extracted, and Kaplan-Meier curves were used for survival analysis.
    Results Maximum 3D diameter (HR=1.829, 95%CI 1.389-2.408, P＜0.001) and spherical disproportion (HR=2.153, 95%CI 1.474-3.146, P＜0.001) were independent risk factors for DFS in primary gastric GIST. Kaplan-Meier curves showed that patients with maximum 3D diameter＞90.5 mm and spherical disproportion＞1.5 showed shorter DFS after curative resection (P＜0.001).
    Conclusion Maximum 3D diameter and spherical disproportion based on preoperative enhanced CT are valuable in the diagnosis of postoperative DFS in primary gastric GIST.

     

    • HTML全文
    • 参考文献(20)
    • 相关文章
    • 施引文献
  • 资源附件(0)

/

返回文章
返回