Abstract: Trace elements and vitamins are essential micronutrients for metabolism. Micronutrients deficiency results in adverse effects on human body, and brings huge challenge to clinical nutrition therapy. To normalize micronutrients application in clinical practice, European Society for Clinical Nutrition and Metabolism (ESPEN) published ESPEN practical short micronutrient guideline on January 2024. Based on previous version published in 2022, current guideline shortens the interpretation of biochemical and physical mechanisms, focuses on micronutrients deficiency and inflammation, recommends the methods of micronutrients assessment and supplementation in different statuses during clinical practices. This paper summarizes specific recommendations and comments for domestic peers to communicate, and provides reference for the management of micronutrient therapy in China.