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Mas相关G蛋白偶联受体X2及白介素与慢性自发性荨麻疹的相关性

Correlations of Mas-related G protein-coupled receptor X2 and interleukin in patients with chronic spontaneous urticaria

    摘要
  • 摘要:
    目的 探讨血清Mas相关G蛋白偶联受体X2（Mas-related G protein-coupled receptor X2, MRGPRX2）以及细胞因子白介素（interleukin, IL）-4、IL-5、IL-6、IL-13、IL-23、IL-33水平与慢性自发性荨麻疹（chronic spontaneous urticaria, CSU）的相关性。
    方法  收集2021年2月至2023年9月在复旦大学附属华山医院皮肤科就诊的55例CSU患者及同期21例健康体检者的基本临床信息和实验室数据，并评估CSU患者的疾病活动度和严重程度。采集所有受试者的外周血，通过酶联免疫吸附试验（enzyme-linked immunosorbent assay, ELISA）检测MRGPRX2，用Luminex多重检测技术检测血清IL-4、IL-5、IL-6、IL-13、IL-23、IL-33水平。采用Spearman相关性分析评价CSU患者的生物标志物与其他参数的相关性，logistic回归分析CSU发生的影响因素。
    结果 CSU组患者血清MRGPRX2水平高于对照组2.41(0, 11.51) ng/mL vs 0(0, 2.86) ng/mL, P＝0.015，IL-23水平高于对照组0.09(0.04, 0.56) pg/mL vs 0.05(0.03, 0.08) pg/mL, P＝0.033。两组受试者其他细胞因子水平差异无统计学意义。重度和非重度CSU患者MRGPRX2及细胞因子水平差异无统计学意义。相关性分析结果显示，CSU患者的血清MRGPRX2水平与IL-4（r＝0.345，P＝0.010）、IL-6（r＝0.395，P＝0.003）水平正相关。Logistic回归分析显示，血清MRGPRX2≥0.055 ng/mL、IL-23≥0.135 pg/mL是CSU发生的独立危险因素（P＜0.05）。
    结论  CSU患者血清MRGPRX2和IL-23水平升高，二者可能参与CSU发病。

     

    Abstract:
    Objective To explore the correlations between serum Mas-related G protein-coupled receptor X2 (MRGPRX2), interleukin (IL)-4, IL-5, IL-6, IL-13, IL-23 and IL-33 levels and chronic spontaneous urticaria (CSU).
    Methods The clinical characteristics and laboratory data from 55 patients with CSU and 21 healthy controls at Huashan Hospital, Fudan University from February 2021 to September 2023 were collected. The disease activity and severity of CSU patients were assessed. Serum level of MRGPRX2 was tested using enzyme-linked immunosorbent assay (ELISA), and levels of IL-4, IL-5, IL-6, IL-13, IL-23, and IL-33 were measured using Luminex multiplex assay in all subjects. Spearman correlation analysis was used to evaluate the correlations between biomarkers and other parameters in CSU patients, and logistic regression analysis was performed to identify factors influencing CSU.
    Results CSU patients exhibited significantly higher serum levels of MRGPRX2 (2.410, 11.51 ng/mL vs 00, 2.86 ng/mL, P＝0.015) and IL-23 (0.090.04, 0.56 pg/mL vs 0.050.03, 0.08 pg/mL, P＝0.033) than healthy controls. There was no difference in levels of other cytokines between the two groups. There was no difference in levels of MRGPRX2 and cytokines between severe and non-severe CSU patients. Correlation analysis showed that serum MRGPRX2 levels in CSU patients were positively correlated with IL-4 (r＝0.345, P＝0.010) and IL-6 (r＝0.395, P＝0.003) levels. Logistic regression analysis indicated that MRGPRX2≥0.055 ng/mL and IL-23≥0.135 pg/mL were independent risk factors for CSU (P＜0.05).
    Conclusions Serum levels of MRGPRX2 and IL-23 in CSU patients are elevated, which may be involved in the pathogenesis of CSU.

     

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