Abstract: With the increase of the prevalence of diabetes in China, the prevalence of diabetes foot is also increasing. In 2021, there are millions of diabetic foot patients in China. At present, the problems of the prevention and treatment of diabetic foot are as follow: delayed diagnosis; multiple departments involved but unable to cooperate; difficulty in follow-up and monitoring; lack of screening and education for high-risk population. In order to solve these problems, we should gradually establish a "multi-disciplinary hierarchical closed-loop management system for diabetic foot" based on the MDT model, which is expected to provide a professional, accurate, systematic, individual, comprehensive and integrated disease management model for diabetic foot patients who have been already diagnosed or at high risk. The system includes horizontal "multi-disciplinary diagnosis and treatment" and vertical "closed-loop hierarchical management". The system focuses on the combination of prevention and treatment. Prevention takes into account the follow-up of key groups, screening of high-risk groups and popular science education of the whole population. In treatment, the basic knowledge training of front-line medical staff is required, consensus on the treatment mode and timing should be reached, and the multidirectional referral channel must be unblocked. Through the establishment of this system, we will gradually achieve the goal of "knowing as much as we should", "preventing as much as we could", and "treating as much as we must" of diabetic foot, form the standard of a multi-disciplinary hierarchical closed-loop management system for diabetic foot, and gradually promote the model in Shanghai, in the Yangtze River Delta, and even the whole country, so as to promote the continuous progress of diabetic foot diagnosis and treatment in our country.