Abstract: Alzheimer disease (AD) is one of the most prevalent neurodegenerative diseases, and its high morbidity would lead to heavy disease burden.As the pathogenesis of AD remains unclarified, current therapies could only slow down the disease progression rather than reverse the disease course.For decades, multiple non-drug treatments have been tested in the clinical trials as well as treatments involving novel developed drugs, and the corresponding outcomes have been disclosed.We reviewed the recently finished and on-going clinical trials focusing on AD in this article.