Abstract: Dry eye disease (DED) is a common ocular disease in the clinic with of incidence. DED has an adverse effect on human health and the quality of life.The diagnosis of DED needs to combine symptoms of patients, such as Sjogren's disease, except for risk factors like age, gender and environment.The therapeutic effect of DED might get better by concerning systemic comorbidiy of patients. In this paper, the correlation between dry eye and systemic comorbidity are summarized.