Abstract: Left atrial appendage closure has become an important treatment to prevent stroke in patients with atrial fibrillation. At present, there are various left atrial appendage closure devices, which have different shapes and structures. However, the left atrial appendage structure is complex and diverse, and a single type of occlusion device can not meet the clinical needs. Therefore, the left atrial appendage closure device has been constantly improved, and the related clinical research has also been a hotspot. The Amulet IDE clinical trial is the first RCT study comparing two commonly used left atrial appendage occluders, and its results have strong guiding significance for the development of transcatheter left atrial appendage closure.