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银屑病患者血清IL-6、IL-25、IL-31表达及其临床意义

Expressions of serum IL-6, IL-25 and IL-31 in patients with psoriasis and their clinical significances

    摘要
  • 摘要:
    目的 探讨细胞因子IL-6、IL-25、IL-31在银屑病免疫炎症中的调节作用。
    方法 选择2013年1月至2014年12月在中国人民解放军空军特色医学中心皮肤科门诊就诊的70例银屑病患者和70例进行健康体检的健康者。采用Sysmex XE-2100全自动流式血细胞分析仪测定银屑病患者外周静脉血中中性粒细胞、淋巴细胞计数，计算中性粒细胞/淋巴细胞比值（NLR）。采用Luminex 200液相芯片检测系统，检测70例银屑病患者血清中IL-6、IL-25、IL-31水平，并与健康对照组相比。
    结果 银屑病组NLR明显高于健康对照组（P < 0.01），疾病进行期升高更明显（P < 0.01）。寻常型银屑病患者NLR较健康对照组升高（P < 0.05），特殊型银屑病患者NLR较寻常型银屑病患者和健康对照组均明显升高（P < 0.01）。NLR与银屑病面积和严重指数（PASI）正相关（P < 0.01）。银屑病组血清IL-6、IL-25、IL-31水平未见异常。特殊型银屑病患者血清IL-6水平高于健康对照组和寻常型银屑病患者（P < 0.05），与NLR正相关（P < 0.05）；特殊型银屑病患者血清IL-25、IL-31水平较寻常型患者下降（P < 0.05），与PASI负相关（P < 0.05），与NLR均负相关（P < 0.01）。
    结论 银屑病作为T细胞介导的全身性免疫炎症反应，涉及多种Th细胞及其相关因子，其中NLR能反映银屑病全身免疫炎症严重程度，而Th2细胞可能通过IL-6、IL-25、IL-31在银屑病Th免疫偏移中发挥调节作用。

     

    Abstract:
    Objective To explore the regulatory roles of IL-6, IL-25, IL-31 in immune inflammation of psoriasis.
    Methods From January 2013 to December 2014, 70 patients with psoriasis and 70 healthy people who received physical examination in the Department of Dermatological of the Air Force Special Medical Center, PLA were selected. The counts of neutrophils and lymphocytes in peripheral venous blood of 70 patients with psoriasis were determined by Sysmex XE-2100 automatic flow cytometry, and the ratio of neutrophils to lymphocytes (NLR) was calculated. The serum levels of IL-6, IL-25 and IL-31 in patients with psoriasis were detected by Luminex 200 liquid phase chip detection system and were compared with that in the healthy control group.
    Results NLR in patients with psoriasis was significantly higher than that in the control group (P < 0.01), and significantly increased during the disease progression period (P < 0.01). NLR in patients with special psoriasis was significantly higher than that in patients with psoriasis vulgaris and the normal controls (P < 0.01). NLR was highly positively correlated with psoriasis area and severity index (PASI, P < 0.01). Serum levels of IL-6, IL-25 and IL-31 in patients with psoriasis were normal Serum level of IL-6 in patients with special psoriasis was higher than that in the normal controls and patients with psoriasis vulgaris (P < 0.05), and was positively correlated with NLR (P < 0.05). The serum levels of IL-25 and IL-31 in patients with special psoriasis decreased than those in patients with psoriasis vulgaris (P < 0.05), which were negatively correlated with PASI (P < 0.05) and NLR (P < 0.01).
    Conclusions Psoriasis as a T cell mediated systemic immune inflammatory response, involves a variety of Th cells and related cytokines. NLR reflects the severity of systemic Immune inflammation in psoriasis, while Th2 cells may play a related regulatory role in Th immune migration in patients with psoriasis through IL-6, IL-25 and IL-31.

     

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