Abstract: Complement C1q/tumor necrosis factor-related proteins (CTRPs) is a hot molecule in recent research fields on inflammatory and metabolic diseases such as coronary heart disease, type 2 diabetes, and obesity. CTRPs have impacts on inflammation activation, vascular endothelial injury, fat metabolism, and blood glucose regulation through multiple signaling pathways. Coronary heart disease is related to vascular inflammation, and mostly accompanied by metabolic diseases. This paper reviews the research progress of CTRPs in coronary heart disease, so to provide new targets for the prevention, diagnosis, and treatment of coronary heart disease.