Abstract: The incidence of pancreatic cancer (PC) is increasing recently. The majority of PC patients are diagnosed at an advanced stage, which results in poor response to the treatment and poor prognosis. At present, several studies have shown that transcatheter interventional chemotherapy could increase the local effective drug concentration, and enhance anti-tumor efficacy, which is better than systemic intravenous chemotherapy in terms of efficacy and side effects. Thus, it has become a promising treatment modality for advanced PC. The combination of transcatheter interventional treatments and other treatments will be the main treatment modality that improves the prognosis of patients with PC. With the deepening of clinical and fundamental research of PC, transarterial interventional therapy will play a more important role.