Objective To compare the clinical effect of different doses of dezocine combined with lidocaine in hysteroscopy.

Methods The data of 888 patients undergoing hysteroscopy in the assisted reproduction outpatient in Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine from January to December in 2020, were retrospectively analyzed. The patients were divided into low-dose dezocine group (group L, n=424) and high-dose dezocine group (group H, n=464). Dezocine (0.02 mg/kg or 0.04 mg/kg) was intravenous injected 5 min before the operation, respectively. At the same time, 5 mL of 2% lidocaine was injected for intraoperative local cervical block anesthesia. According to the clinical characteristics of patients, 816 cases were selected by propensity score matching (PSM), with 408 cases in each group. Intraoperative visual analog score (VAS), body movement rate, Ramsay sedation score, preoperative and intraoperative heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), oxygen saturation (SpO₂), postoperative nausea and vomiting (PONV) were compared between the two groups.

Results After PSM, there were no significant differences in age, weight, operative time, ASA grade, preoperative and intraoperative HR, SBP, DBP, SpO₂ between the two groups. The intraoperative VAS score, body movement rate, and Ramsay sedation score in group H were significantly better than those in group L (P < 0.01). There was no statistical difference in the incidence of PONV between the two groups.

Conclusions For patients undergoing outpatient hysteroscopy, higher dose of dezocine (0.04 mg/kg) intravenous injection combined with lidocaine local anesthesia has better analgesic and sedative effects, and has less adverse reaction.