Abstract: At present, surgical radical resection is still the most effective treatment for hilar cholangiocarcinoma, and the only treatment strategy that is likely to achieve radical cure. Previously, the invasion of the portal vein or hepatic artery by tumors is considered to be a contraindication to surgery, and is a key factor that prevents surgery from reaching the tumor-negative margin (R0 resection). With the development and improvement of vascular surgery technology, these taboos have been partially broken. Until now, the safety and effect of radical resection of hilar cholangiocarcinoma resection combined with portal vein resection have been fully affirmed, which is beneficial to the prognosis of patients and does not significantly increase the perioperative risk. However, there is still disagreement on whether to recombine hepatic artery resection and reconstruction. The purpose of this study is to evaluate the feasibility and safety of radical resection of hilar cholangiocarcinoma with vascular resection and reconstruction.