Abstract: Tumor targeted therapy and immunotherapy are important advances in tumor treatment. With numerous varieties and promising efficacy, targeted drugs and immune checkpoint inhibitors are widely used in clinical practice, which meanwhile triggers a series of adverse events. Among them, cutaneous adverse events are more common. Skin diseases caused by different drugs are distinct, and treatment varies from person to person. Although cutaneous adverse events associated with tumor treatment affect the physical and psychological health of patients, they may indicate better therapeutic effect.