Objective To analyze the effect of continuous blood purification (CBP) on the therapeutic efficiency in septic patients.

Methods A total of 122 patients diagnosed and treated in the Affiliated Hospital of Nantong University from October 2018 to December 2020 were randomly divided into the CBP group and conventional group, with 61 patients in each group. The patients in the conventional group received conventional treatment, and patients in the CBP group received CBP treatment on the basis of conventional treatment. The inflammatory factors (included tumor necrosis factor-α, interleukin-8, and interleukin-6), sepsis indicators, and hospitalization situation between the two groups before and after treatment were compared.

Results There were no statistically significant differences in the inflammatory factors and sepsis indicators between the two groups before treatment. The inflammatory factors and sepsis indicators were lower in the CBP group than those in the conventional group 1 week after treatment (P < 0.01). Compared with the patients of in the conventional group, the length of stay in the intensive care unit and the total length of hospital stay of patients were shorter in the CBP group (P < 0.001), and APACHE Ⅱ scores was also lower in the CBP group (P < 0.01).

Conclusions For patients with sepsis, CBP can effectively suppress the indicators elevated due to sepsis while maintaining body fluid balance, and is hence of great significance in clinical applications.