Abstract:
Objective To explore the safety and efficacy of alteplase intravenous thrombolysis combined with dual antiplatelet therapy in patients with stroke warning syndrome.
Methods From January 2017 to May 2019, 8 patients with stroke early warning syndrome were treated with alteplase intravenous thrombolysis in Zhongshan Hospital, Fudan University and followed up for 6 months. The efficacy of intravenous thrombolysis combined with dual antiplatelet therapy and prognosis of the patients were discussed in conjunction with the literature.
Results Seven patients had cerebrovascular disease risk factors. The frequency of attacks decreased within 24 hours of intravenous thrombolysis, but 6 patients had neurological deficits. By giving dual antiplatelet therapy combined with individualized blood pressure management, the patient's condition was stabilized, and their neurological deficits improved 2 weeks after onset. All patients had a good prognosis 6 months after onset.
Conclusions The alteplase intravenous thrombolysis combined with dual antiplatelet therapy and personalized blood pressure management are beneficial for stabilizing the condition and improving the prognosis of patients with stroke warning syndrome.
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