AGREE Ⅱ评价肝脏弹性成像技术诊断肝纤维化的实践指南与循证解读

陈洁; 中山静子; 程广文; 丁红; 陈世耀

doi:10.12025/j.issn.1008-6358.2021.20202102

AGREE Ⅱ评价肝脏弹性成像技术诊断肝纤维化的实践指南与循证解读

Quality assessment and evidence-based interpretation of clinical practice guidelines on liver elastography in the diagnosis of hepatic fibrosis using AGREE Ⅱ

摘要

摘要:
目的评价已发布的肝脏弹性成像技术无创诊断肝纤维化的实践指南，并从循证方法学角度进行解读。
方法由2名研究者检索中英文数据库，截止日期为2020年9月1日。由3名研究者采用AGREE Ⅱ工具对纳入的指南进行质量评价。
结果共纳入9篇指南。3名研究者的组内相关系数为0.84±0.43，提示一致性很好。纳入指南的AGREE Ⅱ的6个领域得分的中位数分别为78%、30%、33%、81%、42%和47%。
结论现有指南质量参差不齐，指南的参与人员、制订严谨性、应用性和独立性存在不足，须依据更多高质量的临床研究证据，采用循证指南制定法修订。

Abstract:
Objective To evaluate the published practice guidelines on non-invasive diagnosis of hepatic fibrosis using liver elastography, and interpret the assessment from the perspective of evidence-based methodology.
Methods The related data were collected by two researchers based on the Chinese and English databases until September 1, 2020. The methodological quality of included guidelines was evaluated by 3 reviewers using the AGREE Ⅱ.
Results A total of 9 guidelines were included. The intraclass correlation coefficient of the three researchers was 0.84±0.43, indicating that the overall consistency was good. The median scores of the six domains in AGREE Ⅱ were 78%, 30%, 33%, 81%, 42% and 47%, respectively.
Conclusions The quality of the existing guidelines is uneven, and there are deficiencies in the personnel involved, formulation rigorousness, applicability, and independence of the guidelines. The evidence-based method should be adopted for revisions based on more high-quality clinical research evidences.

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