强迫症应激感受对暴露反应预防疗效的影响

王渊; 赵青; 王振

doi:10.12025/j.issn.1008-6358.2021.20201941

强迫症应激感受对暴露反应预防疗效的影响

Effect of perceived stress level on efficiency of exposure and response prevention in obsessive-compulsive disorder patients

摘要

摘要:
目的探讨强迫症（obsessive-compulsive disorder，OCD）患者应激感受水平对暴露反应预防（exposure and response prevention，ERP）疗效的影响。
方法纳入27例符合《美国精神障碍诊断与统计手册第四版》标准并接受ERP治疗的OCD患者。采用耶鲁-布朗强迫量表（Yale-Brown obsessive compulsive scale，Y-BOCS）在治疗前和治疗2周、4周和8周后评估OCD患者的强迫症状严重程度。采用应激感受量表（perceived stress scale-10，PSS-10）评估患者治疗前的应激感受水平。
结果治疗8周后，ERP治疗有效率为40.7%（11/27）。Logistic回归分析显示，治疗前应激感受水平较高的OCD患者ERP疗效较差（OR=0.83，P=0.047）。
结论 ERP可能对治疗前应激感受水平高的患者效果不佳。

Abstract:
Objective To explore how perceived stress affects the efficiency of exposure and response prevention (ERP) in obsessive-compulsive disorder (OCD) patients.
Methods Twenty-seven outpatients meeting the Diagnostic and Statistical Manual of Mental Disorders (fourth edition) criteria for OCD were treated with ERP for 8 weeks. The severity of obsessive-compulsive symptoms were measured with Yale-Brown obsessive compulsive scale (Y-BOCS) at baseline, 2 weeks, 4 weeks, and 8 weeks after treatment. Perceived stress was evaluated with perceived stress scale-10 (PSS-10) before treatment.
Results The response rate of ERP was 40.7%(11/27) 8 weeks after treatment. Individuals with higher pre-treatment levels of perceived stress were less likely to be responsive to ERP (OR=0.83, P=0.047).
Conclusions ERP did not appear to be effective in patients with high level of perceived stress.

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