Abstract: Post-traumatic stress disorder (PTSD) is a mental disorder that occurs after exposure to serious traumatic events. PTSD is a potentially chronic impairing disorder that is characterized by memory invasion, avoidance of trauma-related stimuli, negative cognitive change, enhanced arousal, and aggressive behavior. This article comprehensively reviews the novel progress in clinical diagnostic criteria for PTSD based on the Diagnostic and Statistical Manual of Mental Disorders version 5 (DSM-5) and the International Classification of Diseases version 11 (ICD-11), and also summarizes the novel progress of the first-line psychological therapies in the clinical treatment of PTSD.