Objective To explore the diagnosis and treatment strategy and maternal and fetal outcome of pregnancy with coagulation factor Ⅺ deficiency.

Methods From January 2015 to April 2020, 11 pregnant women with coagulation factor Ⅺ deficiency were selected. Their clinical manifestations, treatment strategies, and maternal and fetal outcomes were retrospectively analyzed.

Results Among the 11 cases of pregnancy with coagulation factor Ⅺ deficiency, 9 cases had a full-term pregnancy, and 2 cases underwent dilatation curettage due to personal factors. Before the operation, fresh frozen plasma was injected to correct the coagulation function, and then cesarean section or dilatation curettage was performed to terminate the pregnancy. Cesarean section was performed in 9 full-term pregnancies, with a postpartum bleeding volume of (500.00 ±291.55) mL, and one case had a postpartum hemorrhage of 1 200 mL. In 2 cases of induced abortion, intraoperative bleeding was about 10 mL. Nine cases were full-term live births, among which one newborn was full-term low birth weight with a birth weight of 1 980 g. All the neonates had no deformity. The Apgar scores of neonates were all 10, and the blood coagulation function was normal.

Conclusions Patients with factor Ⅺ deficiency in pregnancy usually have no bleeding tendency, but their postpartum hemorrhage still needs attention. Preoperative fresh frozen plasma transfusion to correct coagulation function and cesarean section or induced abortion can reduce the occurrence of postoperative bleeding. No abnormal coagulation function was observed in neonates born to the patients with the disease.