人乳头状瘤病毒相关头颈颌面部鳞癌的研究进展

Progress of human papillomavirus-related head, neck, and maxillofacial squamous cell carcinoma

摘要: 头颈部鳞状细胞癌（head and neck squamous cell carcinoma，HNSCC）发病率占头颈部恶性肿瘤的90%，死亡率为40%~50%，来源于口腔、口咽、鼻咽、下咽及喉。通常认为烟草、酒精的过度使用与HNSCC有关，但越来越多的研究表明，人乳头状瘤病毒（human papillomavirus，HPV）感染与HNSCC的发生发展高度相关，尤其是口咽鳞状细胞癌（oropharyngeal squamous cell carcinoma，OPSCC）。本文对HPV相关HNSCC的分子生物学表现、致病机制、治疗进展、预防策略作一综述，为临床及个体化治疗提供新的思路。

Abstract: Head and neck squamous cell carcinoma (HNSCC) accounts for 90% of head and neck malignancies, with a mortality rate of 40%-50%, HNSCC originates from the oral cavity, oropharynx, nasopharynx, hypopharynx, and larynx. It is generally believed that the overuse of tobacco and alcohol is related to HNSCC, but more and more studies show that human papillomavirus (HPV) infection is highly related to the occurrence and development of HNSCC, especially oropharyngeal squamous cell carcinoma (OPSCC). This article reviews the molecular biological performance, pathogenesis, treatment progress, and prevention strategies of HPV-related HNSCC, and provides new ideas for clinical and individualized treatments.