Abstract: Kennedy disease, also known as spinal and bulbar muscular atrophy, is a recessive X-linked genetic disease caused by the abnormal increase of cytosine-adenine-guanine repeat sequence in the first exon of the androgen receptor gene. The main symptoms are muscle weakness and atrophy, involving the bulbar muscles and proximal muscles of the extremities, which may be accompanied by androgen insensitivity such as gynecomastia and sexual dysfunction. Due to the low prevalence rate, clinicians have an insufficient understanding of the disease, especially the androgen insensitivity of patients, which easily leads to misdiagnosis and delay in diagnosis. In this paper, the appearance of androgen insensitivity in Kennedy disease patients was discussed to strengthen the clinicians' understanding of the disease.