A型肉毒毒素治疗三叉神经痛和带状疱疹后神经痛的临床疗效

李华亮; 潘平雷; 陈佳慧; 罗容; 沈媛; 钟建国

doi:10.12025/j.issn.1008-6358.2020.20200752

A型肉毒毒素治疗三叉神经痛和带状疱疹后神经痛的临床疗效

Clinical study on the treatment of trigeminal neuralgia and post-herpetic neuralgia with botulinum toxin type A

摘要

摘要:
目的观察A型肉毒毒素治疗三叉神经痛和带状疱疹后神经痛的临床效果。
方法选取33例三叉神经痛或带状疱疹后神经痛患者，进行疼痛区域A型肉毒毒素皮下或皮内注射治疗，评估患者治疗时、治疗2周后、治疗3个月后疼痛情况(NRS)、睡眠状况及生活质量(QOL)，判断治疗效果，观察药物不良反应。
结果患者使用A型肉毒毒素治疗2周后、3个月后疼痛评分、睡眠评分显著低于治疗时(P < 0.05)，生活质量显著高于治疗时(P < 0.05)，治疗效果好，不良反应少。
结论 A型肉毒毒素治疗三叉神经痛和带状疱疹后神经痛效果显著，可成为神经病理性疼痛治疗的一种新途径。

Abstract:
Objective To observe the clinical effect of botulinum toxin type A (BTX-A) on trigeminal neuralgia (TN) and post-herpetic neuralgia (PHN).
Methods Thirty-three patients with TN or PHN were treated by subcutaneous or intradermal injection of BTX-A into the pain area, the patients' numerical rating scale (NRS), sleep status and quality of life (QOL) at the time of treatment, 2 weeks after treatment, and 3 months after treatment were evaluated, the treatment effect and the drug adverse reactions were analyzed.
Results After 2 weeks and 3 months of treatment with BTX- A, NRS and sleep score of the patients were significantly lower than those at the time of treatment (P < 0.05), QOL was significantly higher than that at the time of treatment (P < 0.05). Treatment effect was good and few side effects were observed.
Conclusions BTX-A is effective in treating TN and PHN and can become a new therapeutic approach for neuropathic pain.

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